William H Konigsberg, PhD
Professor of Molecular Biophysics and Biochemistry
Departments & Organizations
Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development | Biochemistry, Biophysics and Structural Biology: Cell Cycle and Signal Transduction; DNA Dynamics; Transcriptional Regulation
Molecular Biophysics and Biochemistry: Cell Cycle and Transcriptional Regulation | DNA Replication and Repair
Gene Regulation and Functional Genomics
Research Interests
Blood Coagulation; DNA Replication; Genetics; Proteins and Macromolecules more...
Education
- Ph.D., Columbia University, 1956
Selected Publications
- Hogg, M., Aller, P., Konigsberg, W., Wallace, S.S., and Doublie, S. (2007). Structural and biochemical investigation of the role in proofreading of a beta hairpin loop found in the exonuclease domain of a replicative DNA polymerase of the B family. J. Biol. Chem. 282(2):1432-44.
- Zhang, H., Rhee, C., Bebenek, A., Drake, J.W., Wang, J., and Konigsberg, W. (2006). The L561A substitution in the nascent base-pair binding pocket of RB69 DNA polymerase reduces base discrimination. Biochem. 45:2211-2220.
- Luo, G., Wang, M., Konigsberg, W. and Xie, X. Conformational changes in a T7 DNA polymerase-primer/template complex during catalysis observed at a single-molecule level. PNAS 104, 12610-12615 (2007)
