Sandy Chang, PhD, MD

Associate Professor of Laboratory Medicine and of Pathology; Associate Director, Molecular Diagnostics Laboratory

Departments & Organizations

Biological and Biomedical Sciences (BBS): Molecular Medicine, Pharmacology, and Physiology

Radiobiology & Radiotherapy Research

Pathology

Laboratory Medicine: Molecular Diagnostics

Research Interests

Mouse models of cancer; DNA damage; Telomere biology

Education

  • BS, Yale University, 1988
  • Ph.D., Rockefeller University, 1996
  • M.D., Cornell University Medical College, 1997

Selected Publications

  • Wang Y, Shen MF, Chang S. 2011. Essential roles for Pot1b in hematopoietic stem cell self-renewal and survival. Blood Sep 23. [Epub ahead of print]
  • Rai R, Li JM, Zheng H, Lok G, Deng Y, Huen M, Chen J, Jin J and Chang S. The E3 ubiquitin ligase RNF8 stabilizes TPP1 to promote telomere end protection. Nature Structural and Molecular Biology, in press.
  • Flynn RL, Centore RC, O’Sullivan RJ, Rai R, Tse A, Songyang Z, Chang S, Karlseder J, and Zou L. TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA. Nature. 471(7339):532-536.

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