James R Howe, PhD
Professor of Pharmacology
Departments & Organizations
Biological and Biomedical Sciences (BBS): Neuroscience | Biochemistry, Biophysics and Structural Biology: Membrane Biology and Motion; Neurobiology; crystallography, NMR, mass spectrometry, cryo-electron...faculty
Interdepartmental Neuroscience Program
Membrane Proteins - Ion Channels
Membrane Biophysics
Membrane Protein Structure
Neurobiology and Physiology of Synapses
Physiology and Integrative Medical Biology Track
Graduate Program in Cellular and Molecular Physiology
Pharmacology: Neuropharmacology
Research Interests
Glutamate receptors more...
Education
- B.A., University of Minnesota, 1980
- Ph.D., University of Minnesota, 1983
Selected Publications
- Robert, A., Armstrong, N., Gouaux, J.E., and Howe, J.R. (2005). AMPA receptor binding cleft mutations that alter affinity, efficacy, and recovery from desensitization. J. Neurosci. 25:3752-3762.
- Tomita, S., et al. (2005). Stargazin modulates AMPA receptor gating and trafficking by distinct domains. Nature 435:1052-1058.
- Howe, J.R. & Yaksh, T.L. (1982). Changes in sensitivity to intrathecal norepinephrine and serotonin after 6-hydroxydopamine (6-OHDA), 5,6-dihydroxytryptamine (5,6-DHT), or repeated monoamine administration. J. Pharmacol. Exper. Ther. 220, 311-321.
