Frederick J. Sigworth, PhD
Professor of Cellular and Molecular Physiology and of Biomedical Engineering
Departments & Organizations
School of Engineering and Applied Science
High Performance Computation
Biological and Biomedical Sciences (BBS): Neuroscience | Molecular Medicine, Pharmacology, and Physiology | Biochemistry, Biophysics and Structural Biology: Membrane Biology and Motion
Interdepartmental Neuroscience Program
Structural Biology
Cellular & Molecular Physiology: Membrane Proteins - Ion Channels | Membrane Biophysics | Membrane Protein Structure | Cellular Neurophysiology | Physiology and Integrative Medical Biology Track | Graduate Program in Cellular and Molecular Physiology | Sigworth Laboratory
Research Interests
Cell Physiology; Electron Microscopy; Electrophysiology; Ion Channel; Mathematical Model; Patch Clamp; Potassium Channel; Protein Structure; Sodium Channel; Voltage Gated Channel; Xenopus Oocyte more...
Education
- Ph.D., Yale University, 1979
Selected Publications
- Wang L and Sigworth FJ. Structure of the BK potassium channel in a lipid membrane from electron cryomicroscopy. Nature, 461(7261):292-5, 2009.
- Singer A, Coifman RR, Sigworth FJ, Chester DW, Shkolnisky Y. Detecting consistent common lines in cryo-EM by voting. J Struct Biol. 2009 Nov 17. [Epub ahead of print]
- Weerakoon, P.; Sigworth, F.; Culurciello, E.. Integrated patch-clamp biosensor for high-density screening of cell conductance. Electronics Letters, 44:81-82, 2008.
