Claudio R. Alarcón, PhD

Assistant Professor of Pharmacology

Research Organizations

Faculty Research

Selected Publications

  • Lee, H, Goodarzi, H, Tavazoie, SF, Alarcón, CR. TMEM2 is a SOX4 regulated gene that mediates metastatic migration and invasion in breast cancer. Cancer Research. 2016 Sept 1; 76(17): 4994-5005.
  • Alarcón CR, Tavazoie SF. Cancer: Endothelial-cell killing promotes metastasis. Nature. 2016 Aug 11; 536(7615): 154-5.
  • Alarcón, CR, Goodarzi, H, Lee, H, Liu, X, Tavazoie, S. and Tavazoie, SF. HNRNPA2B1 is a mediator of m6A-dependent nuclear RNA processing events. Cell. 2015 Sep 10; 162(6): 1299-1308.
  • Alarcón CR, Lee H, Goodarzi H, Halberg N and Tavazoie SF. N6-methyl-adenosine (m6A) marks primary miRNAs for processing. Nature. 2015 Mar 26; 519(7544): 482-5.
  • Halberg N, Alarcón C, Tavazoie SF. microRNA regulation of cancer-endothelial interactions: vesicular microRNAs on the move. EMBO J. 2012 Aug 29; 31(17): 3509-10.
  • Alarcón C, Zaromytidou AI, Xi Q, Gao S, Yu J, Fujisawa S, Barlas A, Miller AN, Manova-Todorova K, Macias MJ, Sapkota S, Duojia P, Massagué J. Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. Cell. 2009 Nov 13; 139(4): 757-69.
  • Gao S, Alarcón C, Sapkota G, Rahman S, Goerner N, Macias MJ, Erdjument-Bromage H, Tempst P, Massagué J. Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling. Mol Cell. 2009 Nov 13;36(3):457-68.
  • Tavazoie SF, Alarcón C, Oskarsson T, Padua D, Wang Q, Bos PD, Gerald WL, Massagué J. Endogenous Human microRNAs that suppress breast cancer metastasis. Nature. 2008 Jan 11;451(7175):147-52.
  • Sapkota G, Alarcón C, Spagnoli FM, Brivanlou AH, Massagué J. Balancing BMP Signaling through Integrated Inputs into the Smad1 Linker. Mol Cell. 2007 Feb 9;25(3):441-54.
  • Sapkota G, Knockaert M, Alarcón C, Montalvo E, Brivanlou AH, Massagué J. Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways. J Biol Chem. 2006 Dec 29;281(52):40412-9.
  • Gomis RR, Alarcón C, Nadal C, Van Poznak C, Massagué J. C/EBPbeta at the core of the TGFbeta cytostatic response and its evasion in metastatic breast cancer cells. Cancer Cell. 2006 Sep;10(3):203-14.
  • Gomis RR, Alarcón C, He W, Wang Q, Seoane J, Lash A, Massagué J. A FoxO-Smad synexpression group in human keratinocytes. Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12747-52.
  • Knockaert M, Sapkota G, Alarcón C, Massagué J, Brivanlou AH. Unique players in the BMP pathway: small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling. Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):11940-5.
  • Sawchuk DJ, Mansilla-Soto J, Alarcón C, Singha NC, Langen H, Bianchi ME, Lees-Miller SP, Nussenzweig MC, Cortes P. Ku70/Ku80 and DNA-dependent protein kinase catalytic subunit modulate RAG-mediated cleavage: implications for the enforcement of the 12/23 rule. J Biol Chem. 2004 Jul 9;279(28):29821-31.
  • Xu L, Alarcón C, Col S, Massagué J. Distinct domain utilization by Smad3 and Smad4 for nucleoporin interaction and nuclear import. J Biol Chem. 2003 Oct 24;278(43):42569-77.

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