Molecular Medicine, Pharmacology, and Physiology

Anderson, Karen

Professor of Pharmacology
Co-Director Therapeutics/Chemotherapy Program

Research Interests:Enzyme function; Anti-viral agents

Aronson, Peter

C. N. H. Long Professor of Medicine (Nephrology) and Professor of Cellular and Molecular Physiology

Research Interests:Urinary electrolyte excretion; cell membrane ion exchangers; proximal tubule

Bale, Allen

Professor of Genetics
Director, DNA Diagnostic Lab

Research Interests:Molecular Mechanisms of Cancer; Predisposition and Developmental Defects; DNA Diagnostics; Birth Defects; Cancer; Fanconi; Genetics; Hedgehog; Multiple Endocrine Neoplasia; Patched; Skin Cancer; Tumor Suppressor

Beardsley, George

Professor of Pediatrics

Research Interests:Biology of Osteosarcoma; Molecular enzymology of purine biosynthesis indicators for osteosarcoma; Molecular Pharmacology of anticancer and antiviral drugs which alter DNA structure; Biochemical Pharmacology of antifolate drugs; Development of novel antifolates

Ben Mamoun, Choukri

Associate Professor of Medicine (Infectious Diseases) and of Microbial Pathogenesis

Research Interests:Malaria

Bender, Jeffrey

Robert I. Levy Professor of Medicine (Cardiology) and Professor of Immunobiology
Associate Chief, Cardiovascular Medicine

Research Interests:Inflammatory, Immune, Metabolic and Hormonal Effects on the Endothelium

Bennett, Anton

Associate Professor of Pharmacology and of Comparative Medicine
Co-Director, Program in Integrative Cell Signaling and Neurobiology of Metabolism
Director, BBS Minority Affairs

Research Interests:Signal transduction; Protein tyrosine phosphatases; Cancer; Diabetes; Obesity; Muscle stem cells; Muscular dystrophy

Bordey, Angelique

Associate Professor of Neurosurgery and of Cellular and Molecular Physiology

Research Interests:Neurogenesis; stem cells; neurotransmitters; growth factor signaling; astrocytes; tuberous sclerosis complex; epilepsy; glioma

Bosenberg, Marcus

Associate Professor of Dermatology and of Pathology

Research Interests:Melanocytic neoplasms; soft tissue tumors; cutaneous lymphoma; genodermatoses

Boulpaep, Emile

Professor of Cellular and Molecular Physiology
Director Medical Studies, Director of Graduate Studies, Cellular and Molecular Physiology

Research Interests:Electrical properties of membrane proteins in plasma membranes and junctions of renal tubule cells

Braddock, Demetrios

Associate Professor of Pathology

Research Interests:Structural biology; Hematopathology; Genitourinary Pathology

Brash, Douglas

Professor of Therapeutic Radiology, of Dermatology and of Genetics

Research Interests:Ultraviolet Light; Skin Cancer

Brown, Thomas

Professor of Psychology and of Cellular and Molecular Physiology

Research Interests:Neurobiological mechanism of learning and memory.

Bucala, Richard

Professor of Medicine (Rheumatology), of Epidemiology (Microbial Diseases) and of Pathology and Residential College Associate Fellow in Faculty of Arts and Sciences

Research Interests:Mechanisms by which host immunity converts from a protective response to one producing disease and tissue pathology; Emergence of steroid resistance; Biochemical, biological, and genetic characterization of cytokine MIF; MIF's role in malaria; Role of fibrocytes in different systemic fibroses

Canessa, Cecilia

Professor of Cellular and Molecular Physiology and of Medicine (Nephrology)

Research Interests:Renal Function; Epithelial Sodium Channels

Cantley, Lloyd

C. N. H. Long Professor of Medicine (Nephrology) and Professor of Cellular and Molecular Physiology
Associate Chair, Research

Research Interests:Nephrology; physiology and integrative medical biology; epithelial cell migration and morphogenesis; epithelial cell adhesion; migration; branching tubulogenesis

Caplan, Michael

C. N. H. Long Professor of Cellular and Molecular Physiology and Professor of Cell Biology
Chair, Cellular and Molecular Physiology

Research Interests:Ion pumps in polarized epithelia; Sorting and function

Carrasco, Nancy

Professor of Cellular and Molecular Physiology

Chang, Sandy

Associate Professor of Laboratory Medicine and of Pathology
Associate Director, Molecular Diagnostics Laboratory

Research Interests:Mouse models of cancer; DNA damage; Telomere biology

Cheng, Yung-Chi

Henry Bronson Professor of Pharmacology
Director, Therapeutics/Chemotherapy Program
Chairman, Consortium for the Globalization of Chinese Medicine (CGCM)

Research Interests:Cancer; Viral chemotherapy

Cho, Judy

Associate Professor of Medicine (Digestive Diseases) and of Genetics
Director, Inflammatory Bowel Disease Center

Research Interests:Inflammatory Bowel Disease (IBD); identifying genetic variation that affects susceptibility to and expression of Inflammatory Bowel Disease (IBD)

Cohen, Lawrence

Professor of Cellular and Molecular Physiology

Research Interests:Brain; Central Nervous System; Neurons; Vertebrate Physiology; Olfaction; Olfactory Bulb; Protein Sensors of Voltage and Calcium

Costa, Jose

Professor of Pathology and of Medicine (Medical Oncology)
Director, Translational Diagnostics
Director, Musculoskeletal Tumor Program

Research Interests:Oncology: carcinogenesis, tumor development and progression; Advanced Diagnostics; Molecular Diagnostics; Diagnosed Genetic Alterations in Tumors; Cancer Risk Detection by Mutational Load Distribution Analysis

Craft, Joseph

Paul B. Beeson Professor of Medicine (Rheumatology) and Professor of Immunobiology
Section Chief, Rheumatology
Program Director, Investigative Medicine
Paul B. Beeson Professor of Medicine

Research Interests:Arthritis; Autoimmunity; Cytokines; Diseases and Disorders; Lupus; T Cell Differentiation; T Cells; Tolerance

Dhodapkar, Madhav

Arthur H. and Isabel Bunker Professor of Medicine (Hematology) and Professor of Immunobiology
Chief, Section of Hematology, Department of Internal Medicine
Director of Hematologic Malignancies, Yale Cancer Center

Research Interests:Myeloma and related plasma cell disorders; human immune system's interaction with growing tumors in patients; preneoplastic monoclonal gammopathy and multiple myeloma, tumor and host related factors

DiGiovanna, Michael

Associate Professor of Medicine (Medical Oncology) and of Pharmacology

Research Interests:Breast cancer; HER-2/neu/ErbB-2; IGF1 receptor; EGF receptor; other growth factor receptor tyrosine protein kinases in malignancy; estrogen receptor, signal transduction

Duman, Ronald

Elizabeth Mears and House Jameson Professor of Psychiatry and Professor of Neurobiology and of Pharmacology
Director, Abraham Ribicoff Research Facilities

Research Interests:Depression; Antidepressants; Stress; Molecular biology; Neuropharmacology Signal transduction pathways; Gene expression; Identifying the molecular and cellular adaptations that underlie the actions of psychotropic drugs and stress

Egan, Marie

Associate Professor of Pediatrics (Respiratory) and of Cellular and Molecular Physiology
Director, Cystic Fibrosis Center

Research Interests:Cystic fibrosis clinical studies; Cystic fibrosis basic science research (ion transport, Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) function); Cystic fibrosis translational research studies (strategies to bypass the basic defect)

Ehrlich, Barbara

Professor of Pharmacology and of Cellular and Molecular Physiology

Research Interests:Intracellular calcium regulation

Elias, Jack

Waldemar Von Zedtwitz Professor of Medicine and Professor of Immunobiology
Chair, Department of Internal Medicine

Research Interests:Cell and Molecular biology of lung injury and repair; Asthma; COPD; Pulmonary fibrosis; acute lung injury; Cytokines; Inflammation; Internal Medicine; Pulmonary Diseases; Transgenic mice, genetically modified mice; Emphysema; Fibrosis; Inflammation

Ellman, Jonathan

Professor of Chemistry
Pharmacology

Research Interests:proteases, phosphatases, inhibitors, C-H functionalization, asymmetric amine synthesis

Eswarakumar, V.

Assistant Professor of Orthopaedics and Rehabilitation and of Pharmacology

Forbush, Biff

Professor of Cellular and Molecular Physiology

Research Interests:Membrane Proteins; Epithelial Transport; Ion Transport; Na-K-Cl Cotransporter; Nerve Cells; Muscle Cells

Geibel, John

Professor of Surgery (Gastrointestinal) and of Cellular and Molecular Physiology
Vice Chair, Surgery
Director, Surgical Research

Research Interests:Gastric Acid Secretion; Colonic Fluid Transport; Renal Physiology; Intracellular Ion Activity Measurements; Calcium Sensing Receptor; Diarrheal disease, electrophysiology; CFTR; AMPKinase volume regulation

Greco, Valentina

Assistant Professor of Genetics and of Dermatology

Research Interests:Organ Regeneration in Vertebrate Systems; Stem Cells; Stem Cell Niche Organization; Cancer

Grutzendler, Jaime

Associate Professor of Neurology and of Neurobiology

Research Interests:two-photon microscopy, neurodegeneration,Alzheimer's, blood-brain barrier, microvasculature, synapses, neuroinflammation, microglia, astrocyte, endothelium

Ha, Ya

Associate Professor of Pharmacology

Research Interests:Membrane proteins

Hodsdon, Michael

Associate Professor of Laboratory Medicine and of Pharmacology
Assoc. Director, Clinical Chemistry Laboratory

Research Interests:Biochemistry; Biophysics; Breast Cancer; Clinical Chemistry; Drug Metabolism; Health and Medicine; Laboratory Practice or Procedure; Nuclear Magnetic Resonance; Pathobiology; Pharmacology; Spectroscopy; Structural Biology; Toxicology

Hurwitz, Michael

Assistant Professor of Medicine (Medical Oncology)

Research Interests:cell migration; kinase signaling; phosphorylation; cytoskeleton; engulfment; apoptosis; C. elegans; cancer biology

Jordt, Sven-Eric

Associate Professor of Pharmacology

Research Interests:Sense of touch and pain in humans and animals; Chemosensory processes in sensory neurons and their role in chemical environmental exposures; Neural sensitization in asthma; Other hypersensitivity disorders

Kaczmarek, Leonard

Professor of Pharmacology and of Cellular and Molecular Physiology

Research Interests:Neuroscience; Learning and memory; Ion channels

Kazmierczak, Barbara

Associate Professor of Medicine (Infectious Diseases) and of Microbial Pathogenesis

Research Interests:Pseudomonas aeruginosa; Staphylococcus aureus; innate immunity; host-pathogen interactions; mucosal immunity

Kibbey, Richard

Assistant Professor of Medicine (Endocrinology) and of Cellular and Molecular Physiology

Research Interests:Mechanisms of insulin secretion by beta-cells; pathogenesis of beta-cell exhaustion in Type 2 Diabetes Mellitus; mitochondria

Kluger, Yuval

Associate Professor of Pathology

Research Interests:Signal processing and dimensional reduction of genome-wide data; Local and non-local genomic pattern recognition; Identification of cancer subclones with proliferation and invasion potential in heterogeneous cancer biopsies

Krause, Diane

Professor of Laboratory Medicine, of Cell Biology and of Pathology
Assoc. Director, Yale Stem Cell Center
Assoc. Director, Transfusion Medicine Service
Director, Frisbee Laboratory for Hematopoietic Graft Engineering

Research Interests:Bone Marrow Transplantation; Stem Cells; Cell Molecular Biology; Hematology; Leukemia

Krauthammer, Michael

Associate Professor of Pathology

Research Interests:Molecular interaction networks: computational analysis, pathway discovery, knowledge representation; Statistical modeling and analysis; Text mining in biology: term identification, information extraction

Kupfer, Gary

Professor of Pediatrics (Hematology / Oncology) and of Pathology
Director, Pediatric Oncology Program
Section Chief, Pediatric Hematology/Oncology

Research Interests:Genomic instability; Development of cancer; Genetic syndrome Fanconi anemia (FA); Viral protein enhancement of cancer therapeutics

Kyriakides, Themis

Associate Professor of Pathology and of Biomedical Engineering

Research Interests:Angiogenesis; Extracellular matrix remodeling; Inflammation; Cell fusion; Wound healing; Foreign body response; Gene delivery; Biomaterials

Lizardi, Paul

Professor of Pathology

Research Interests:Cancer Genetics/Epigenetics; Cancer biology; Dynamics of abnormal chromatin states in neoplasia and metastasis; DNA amplification technology (MDA, RCA); DNA microarray technology for epigenetic analysis, array-CGH; Proteomics analysis of cancer tissues

Lolis, Elias

Professor of Pharmacology
Director of Graduate Studies

Research Interests:Cancer; Inflammation; Infectious disease; macromolecular X-ray crystallography; Signaling pathways; Drug Design; High throughput screening (HTPS)

Madri, Joseph

Professor of Pathology

Research Interests:Connective tissue disorders; Cell-Matrix and Cell-Cell Interactions; Integrin-Mediated Signaling; Cardio-vascular development; Angiogenesis and Vascular Biology; inflammation; T-cell-Endothelial cell interactions

Maihle, Nita

Professor of Obstetrics, Gynecology, and Reproductive Sciences, of Pathology and of Pharmacology
Director, Biology of Reproductive Tract Cancers Program

Research Interests:Cancer; Women's cancers; Diagnostics; Theragnostics; Biotherapeutics; Precision/personalized medicine, signal transduction; EGFR/ERBB/HER-driven adult solid tumors

Martin, Kathleen

Associate Professor of Medicine (Cardiology)

Research Interests:vascular smooth muscle; differentiation; signal transduction; transcription; translation

Means, Robert

Associate Professor of Pathology
Director of Graduate Admissions, Microbiology Program

Research Interests:Viruses; Immune responses; AIDS-associated cancers; KSHV; Adverse pregnancy events; Oncogenesis; Cancer metabolism; Tumor virology; Herpesviruses

Min, Wang

Associate Professor of Pathology

Research Interests:Cytokine signaling; angiogenesis; Biology of vascular endothelium; gene therapy

Miranker, Andrew

Associate Professor of Molecular Biophysics and Biochemistry

Research Interests:Conformational changes in proteins which give rise to a special class of protein complex known as amyloid fibrils

Morrow, Jon

Raymond Yesner Professor of Pathology
Chair, Department of Pathology
Chief of Pathology at YNHH

Research Interests:Hemolytic Disease; Degenerative Brain Disease; spectrin; Autopsy Pathology; Renal Pathology; Medical Informatics; Computer Aided Instruction (CAI); Telepathology

Nairn, Angus

Charles B. G. Murphy Professor of Psychiatry and Professor of Pharmacology

Research Interests:Dopaminergic signal transduction; Structure and function of protein kinases and phosphatases

Nathanson, Michael

Professor of Medicine (Digestive Diseases) and of Cell Biology
Section Chief, Digestive Diseases
Director, Yale Liver Center
Director, Center for Cell and Molecular Imaging

Research Interests:Mechanisms and effects of calcium signals in polarized epithelia; effect of spatial organization of calcium signals on organ function regulation; factors that organize Ca2+ waves in hepatocytes; organization and effects of Ca2+ waves in cholangiocytes; mechanisms and effects of Ca2+ signals in the nucleus

Nguyen, Don

Assistant Professor of Pathology

Research Interests:Metastasis; Lung cancer; Cancer genomics; Tumor microenvironment

Nitabach, Michael

Associate Professor of Cellular and Molecular Physiology and of Genetics

Research Interests:Neurophysiology; Molecular genetics; Systems Physiology; Animal Behavior

Paintsil, Elijah

Assistant Professor of Pediatrics (Infectious Disease) and of Pharmacology

Research Interests:HIV translational research: cellular pharmacology of HIV-RT Inhibitors in relation to clinical toxicities; Fitness and evolution of HIV drug resistant mutants; Molecular epidemiology and dynamics of HIV/HCV transmission

Picciotto, Marina

Charles B. G. Murphy Professor of Psychiatry and Professor of Neurobiology and of Pharmacology
Assistant Chair for Basic Science Research, Dept. of Psychiatry

Research Interests:Neuroscience; Molecular basis of behavior; Intracellular signaling; Mouse genetic models

Pieribone, Vincent

Associate Professor of Cellular and Molecular Physiology and of Neurobiology
Associate Fellow, John B. Pierce Laboratory

Research Interests:Neurophysiology; Neurotransmission; Voltage dye imaging; sensory physiology; drug development; coral biology; fluorescent proteins

Pober, Jordan

Ensign Professor of Immunobiology and Professor of Dermatology and of Pathology
Director, Human and Translational Immunology Program
Vice-Chair, Dept. of Immunobiology for the Section of Human and Translational Immunology

Research Interests:Immunobiology of vascular endothelial cells: cytokine actions and mechanisms; transplantation immunology

Politi, Katerina

Assistant Professor of Medicine (Medical Oncology) and of Pathology

Research Interests:Cancer biology; Mouse models of lung cancer; Epidermal Growth Factor Receptor; ERBB Receptor family; Targeted therapy

Rimm, David

Professor of Pathology
Director of Medical Studies
Director of Pathology Tissue Services

Research Interests:Quantitative Pathology; Cancer Tissue Biomarkers; Melanoma, Breast Cancer; Cell-cell adhesion in cancer; Translation of molecular techniques to diagnostic cytopathology; General Cytopathology; Immunohistochemistry; thyroid pathology

Rinehart, Jesse

Assistant Professor of Cellular and Molecular Physiology

Research Interests:Ion Transport; Kinase/Kinome Interactions in Physiological Systems; System-Wide & Targeted Phosphoproteomics; Protein Engineering

Rockwell, Sara

Professor of Therapeutic Radiology and of Pharmacology
Associate Dean for Scientific Affairs

Research Interests:Microenvironmental Heterogeneity in Solid Tumors; Experimental Cancer Therapy; Biological Effects of Ionizing Radiation; Effects of Hypoxia and low pH

Rodeheffer, Matthew

Assistant Professor of Comparative Medicine and of Molecular, Cellular, and Developmental Biology

Research Interests:Genomics; Stem Cells

Roth, Robert , Jr

Professor of Psychiatry and of Pharmacology

Research Interests:Neurotransmitter function; Psychotropic drugs; Catecholamin-containing neurons

Rudnick, Gary

Professor of Pharmacology

Research Interests:Neurotransmitter recycling; Mechanism of membrane transport

Saltzman, W. Mark

Goizueta Foundation Professor of Biomedical Engineering and Professor of Cellular and Molecular Physiology and of Chemical Engineering
Department Chair, Biomedical Engineering

Research Interests:Bio-compatible polymers, drug delivery systems

Santos-Sacchi, Joseph

Professor of Surgery (Otolaryngology), of Cellular and Molecular Physiology and of Neurobiology

Research Interests:Mammalian inner ear

Sessa, William

Alfred Gilman Professor of Pharmacology and Professor of Medicine (Cardiology)
Vice Chairman, Pharmacology
Director, Vascular Biology & Therapeutics Program

Research Interests:Vascular endothelium and inflammation; MiRNAs; Vascular development and angiogenesis; Lipid domains and signaling; Atherosclerosis

Shadel, Gerald

Professor of Pathology and of Genetics
Director, Graduate Studies Experimental Pathology Graduate Program

Research Interests:Mitochondrial Genetics and Biogenesis; Mitochondrial Dysfunction in Human Disease and Aging; Mechanisms of mtDNA Transcription and Mitochondrial Translation; Signaling Pathways that Sense and Control Mitochondrial Function

Shlomchik, Mark

Professor of Laboratory Medicine and of Immunobiology
Associate Director, Transfusion Service

Research Interests:Autoimmunity; Blood or Blood Products or Transfusions; Bone Marrow Transplantation; Immunobiology; Immunology; Immunopathology; Immunotherapy; Lymphocytes; Transgenic Animals

Shulman, Gerald

George R. Cowgill Professor of Medicine (Endocrinology) and Professor of Cellular and Molecular Physiology
Investigator, Howard Hughes Medical Institute

Research Interests:Molecular mechanisms responsible for insulin resistance

Sigworth, Frederick

Professor of Cellular and Molecular Physiology and of Biomedical Engineering

Research Interests:Cell Physiology; Electron Microscopy; Electrophysiology; Ion Channel; Mathematical Model; Patch Clamp; Potassium Channel; Protein Structure; Sodium Channel; Voltage Gated Channel; Xenopus Oocyte

Simons, Michael

Robert W. Berliner Professor of Medicine (Cardiology) and Professor of Cell Biology
Section Chief, Cardiovascular Medicine
Director, Yale Cardiovascular Research Center

Research Interests:Angiogenesis; Arteriogenesis; Endothelial Signaling; tyrosine kinase signaling; vascular development; FGF; VEGF; endocytosis

Singh, Satinder

Assistant Professor of Cellular and Molecular Physiology

Research Interests:Chemical neurotransmission; Neuropsychiatric disease; Epilepsy; Neuropharmacology; Biogenic amine; Gamma-aminobutyric acid; Neurotransmitter transporter; Antidepressant; Structural neurobiology; X-ray crystallography; Transporter kinetics

Sklar, Jeffrey

Professor of Pathology and of Laboratory Medicine
Director, Molecular Diagnostics Program
Director, Molecular Genetics Pathology Fellowship
Director, Molecular Tumor Profiling Laboratory

Research Interests:Molecular biology of human disease, especially cancer; Molecular biologic methods of disease diagnosis; Cancer-related genes and their functions in neoplasia and normal cellular physiology; Chromosomal structure and chromosomal abnormalities in genetic and neoplastic disorders; Immunogenetics

Slayman, Clifford

Professor of Cellular and Molecular Physiology

Research Interests:Charge-dependent Transport; Proton Pumps; Potassium channels; Ribosomally Synthesized AntiMicrobial Peptides (RAMPs)

Somlo, Stefan

C. N. H. Long Professor of Medicine (Nephrology) and Professor of Genetics
Chief, Section of Nephrology

Research Interests:Genetic kidney and liver disease; Cilia function in tissue homeostasis; Polycystin function

Spiegel, David

Assistant Professor of Chemistry

Research Interests:Design of novel molecules that enhance the recognition of various pathogens, including viruses, by the human immune system

Stern, David

Professor of Pathology
Associate Director, Shared Resources, Yale Cancer Center
Leader, Signal Transduction Research Program, Yale Cancer Center

Research Interests:Cancer Biology: signal transduction by HER2/ErbB2 and other EGF family receptor tyrosine kinases; EGF family receptors in breast cancer and mammary development; DNA damage checkpoint signaling; Functional and genetic analysis of cancer; Melanoma

Tomita, Susumu

Associate Professor of Cellular and Molecular Physiology
Primary faculty, Program in Cellular Neuroscience, Neurodegeneration and Repair

Research Interests:Synaptic transmission; Brain; Biochemistry; molecular biology; immunocytochemistry; gene-targeted animals; electrophysiology

Turk, Benjamin

Associate Professor of Pharmacology

Research Interests:Cell signaling; Protein kinases; Chemical biology; Proteomics; Metalloproteases; Protein engineering

Wajapeyee, Narendra

Assistant Professor of Pathology

Research Interests:Cancer; Genomics; RNAi; Senescence; DNA methylation; RNAi delivery to cancer cells

Walther, Zenta

Associate Professor of Pathology
Medical Director, YNHH Tumor Profiling Laboratory

Research Interests:epithelial polarity and proliferation control; intestinal epithelial homeostasis; intestinal barrier function; innate immune signalling

Wang, Tong

Professor of Cellular and Molecular Physiology

Research Interests:Kidney tubule transport; Electrolyte and acid-base balance; Transgenic animal models and human disease

Waxman, Stephen

Bridget Marie Flaherty Professor of Neurology and Professor of Neurobiology and of Pharmacology
Director, Center for Neuroscience and Regeneration Research

Research Interests:Axons; Electrophysiology; Genes; Ion Channels; Molecular Biology; Multiple Sclerosis; Pain Syndromes; Sodium Channels; Spinal Cord Injury; Stroke

Weissman, Sherman

Sterling Professor of Genetics

Research Interests:Globin and Histocompatibility Gene Structure and Function; Genome wide mapping of gene activity and chromosome structure in man; Transcription Factors; Lymphocyte and myeloid Transcription Networks; Stem Cells; Cell Senescence; Methods for Molecular Genetics