All of bioinformatics deals with biological information. What is the best way of storing and organizing this on the computer? How does one best connect different types of information (e.g. protein features and expression data)? How can we interconnect distributed databases, handle terabytes of data, and provide biologically meaningful queries? Storing, managing, and accessing information is a non-trivial complex process that is one of the foundations of bioinformatics. Yale has long-standing strength in biomedical informatics as well as research in the development and interoperation of heterogeneous biomedical databases and related tools.